Clinical Research & Neurobiology
8 min read
• Updated 2026-09-13
Magic Mushroom Potency Scale & Alkaloid Concentration Chart (2026)
An empirical potency ranking of major entheogenic mushroom species based on combined psilocybin, psilocin, baeocystin, and aeruginascin concentrations.
The Fungal Alkaloid Potency Spectrum
Total active tryptamine concentration varies dramatically across species. Below is the HPLC laboratory concentration comparison by percentage of dry weight:
| Species | Psilocybin (%) | Psilocin (%) | Total Alkaloids | Relative Potency |
|---|---|---|---|---|
| Psilocybe azurescens | 1.78% | 0.38% | ~2.50% | 3.5x Standard |
| Psilocybe cyanescens | 1.35% | 0.41% | ~1.95% | 2.7x Standard |
| Psilocybe natalensis | 1.20% | 0.35% | ~1.80% | 2.2x Standard (Very Smooth) |
| Psilocybe semilanceata (Liberty Cap) | 0.98% | 0.02% | ~1.15% | 1.6x Standard |
| Psilocybe cubensis (Standard) | 0.60% | 0.15% | ~0.85% | 1.0x (Baseline Reference) |
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Medical & Harm Reduction Disclaimer: This article is provided for educational and harm reduction purposes only. It is not intended as medical advice. Always consult a qualified healthcare provider.