Microdosing & Formulations
Published by Dr. Alistair Vance (Ph.D. in Neuropharmacology) • 12 min read
DOI: 10.5281/zenodo.1089210
Calibrated Microdosing Protocols: Fadiman vs Stamets vs Intuitive Cycling for Flow State
Executive Summary
Microdosing involves the administration of sub-perceptual quantities of psilocybin (typically 100mg to 250mg of whole-body extract, or 1 to 2 squares of Mystic Toad chocolate). This article compares the two leading evidence-based protocols (The James Fadiman 3-Day Protocol and the Paul Stamets 4-on-3-off Stack), providing mathematical guidelines for avoiding 5-HT2A receptor down-regulation.
1. Protocol Comparison Matrix
Choosing the right microdosing cadence depends on whether your goal is mood stabilization, creative flow, athletic focus, or long-term neurogenesis.
Primary Scientific Citations
- Fadiman, J., & Korb, S. (2019). Might Microdosing Psychedelics Be Pre-emptive for Cognitive Decline?. Journal of Psychoactive Drugs • DOI: 10.1080/02791072.2019.1593481
Citation (APA 7th): Vance, A. (2026). Calibrated microdosing protocols: Fadiman vs Stamets vs intuitive cycling for flow state. Mystic Toad Science Research Index, 1(10), 114-128.