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Harm Reduction & Protocols Published by Marcella Thorne (M.Sc. in Phytochemistry & Botanical Extraction) • 8 min read DOI: 10.5281/zenodo.1089213

Eliminating Shroom Nausea: The Role of Fungal Chitinase, 5-HT3 Receptors and Hydro-Thermal Extraction

Executive Summary

The notorious 'shroom stomach cramp' is caused by two biological factors: (1) human inability to digest tough fungal cell walls made of beta-chitin, and (2) direct stimulation of peripheral 5-HT3 serotonin receptors in the gut lining. By employing dual hydro-thermal extraction to isolate pure alkaloids and discarding raw fungal fiber, Mystic Toad chocolates eliminate nausea entirely.

1. The Anatomy of Fungal Chitin Indigestion

Raw dried mushrooms contain fibrous beta-glucan and chitin matrices identical to the exoskeletons of crustaceans. When ingested whole, the stomach secretes excess hydrochloric acid in a futile attempt to digest the chitin, causing cramping and gas.

Mystic Toad completely purges all insoluble fungal fibers, delivering pure active psilocin encapsulated in luxurious cacao butter.

Primary Scientific Citations

  • Bousquet, E., & Miller, J. (2021). Gastrointestinal tolerability of fungal extracts vs raw biomass in botanical preparations. Fitoterapia • DOI: 10.1016/j.fitote.2021.104991
Citation (APA 7th): Thorne, M. (2026). Eliminating shroom nausea: The role of fungal chitinase, 5-HT3 receptors and hydro-thermal extraction. Mystic Toad Science Research Index, 1(13), 153-163.